Linked Life Data

19932091

Source:http://linkedlifedata.com/resource/pubmed/id/19932091

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
2010-1-27
pubmed:abstractText
The basis of Gilbert's syndrome is a 70% reduction in bilirubin glucuronidation which, in the Caucasian population, is the result of a homozygous TA insertion into the promoter region of the UDP-glucuronosyltransferase 1A1 (UGT1A1) gene (UGT1A128 allele). In addition, homozygous subjects for UGT1A128 genotype may suffer from severe irinotecan toxicity or jaundice during treatment with the protease inhibitor atazanavir. For these reasons it is very important to perform a correct molecular diagnosis. In this study, we describe for the first time a new high resolution melting (HRM) analysis for a rapid UGT1A1 (TA)(n) genotyping.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1873-3492
pubmed:author
pubmed:copyrightInfo
Crown Copyright 2009. Published by Elsevier B.V. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
411
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
246-9
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Rapid UGT1A1 (TA)(n) genotyping by high resolution melting curve analysis for Gilbert's syndrome diagnosis.
pubmed:affiliation
Laboratory of Clinical Molecular Biology, Institute of Biochemistry & Clinical Biochemistry, University Hospital A.Gemelli, Catholic University of the Sacred Heart, Rome, Italy. angelo.minucci@virgilio.it
pubmed:publicationType
Journal Article