Linked Life Data

19931644

Source:http://linkedlifedata.com/resource/pubmed/id/19931644

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-12-16
pubmed:abstractText
We found that temperature and photoperiod significantly influence the transcription of the estrogen-responsive genes, vitellogenin1 (Vtg1), vitellogenin2 (Vtg2), estrogen receptor-alpha (ER alpha) and estrogen receptor-beta (ER beta), after a 21-day exposure to environmentally relevant concentrations of 17 alpha-ethynylestradiol (EE2), nonylphenol (NP) and EE2 plus NP (EE2+NP). In general, gene transcription levels were higher as temperature and photoperiod length increased. The mRNA levels of Vtg1 in EE2 (10 ng/L) and EE2+NP (10 ng/L and 25 microg/L, respectively) groups were induced more than 10(4) times both in 21 degrees C-12L and 30 degrees C-14L groups, but only 369+/-23 and 178+/-59-fold induced in 12 degrees C-10L group compared to the control, respectively. Specifically, when exposed to a high concentration of NP (25 microg/L) for 21 days, the levels of all mRNAs examined were significantly increased (p<0.05) in the 21 degrees C-12L and the 30 degrees C-14L groups compared to the controls. However, no obvious induction in transcription was observed in the 12 degrees C-10L group. The results obtained in the present study clearly elucidate that temperature and photoperiod greatly influence the effect of EDCs, and thus suggest that to fully define the endocrine disruption effects seasonal and/or climate change effects must also be investigated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1532-0456
pubmed:author
pubmed:issnType
Print
pubmed:volume
151
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
258-63
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Temperature and photoperiod affect the endocrine disruption effects of ethinylestradiol, nonylphenol and their binary mixture in zebrafish (Danio rerio).
pubmed:affiliation
College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't