Linked Life Data

19931459

Source:http://linkedlifedata.com/resource/pubmed/id/19931459

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-2-9
pubmed:abstractText
Recent years have witnessed growing interest in the biology of invadopodia, proteolytically active protrusions formed by invasive tumor cells when cultured on an extracellular matrix (ECM). Although substantial progress has been made towards defining their basic elements and features, the need remains to understand how these components are recruited and, ultimately, how ECM degradation is so precisely localized. According to recent evidence, invadopodia are raft-like membrane domains where cholesterol levels are tightly regulated, and active transport of protease-delivering carriers is required for their function. On this basis we hypothesize that the correct delivery of cargo to invadopodia is ensured by a polarized, cholesterol-dependent trafficking mechanism, similar to that of the apical domain of epithelial cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1879-3088
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
64-70
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Aiming for invadopodia: organizing polarized delivery at sites of invasion.
pubmed:affiliation
Tumor Cell Invasion Laboratory, Consorzio Mario Negri Sud, S. Maria Imbaro (Chieti), 66030 Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't