Linked Life Data

19930620

Source:http://linkedlifedata.com/resource/pubmed/id/19930620

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2010-1-25
pubmed:abstractText
High mobility group box protein 1 (HMGB1) has been shown to participate in acute inflammatory reactions, including acute lung injury and sepsis. There is also evidence that circulating levels of HMGB1 are increased after severe trauma and are associated with clinically important outcome parameters, including mortality. Recent studies demonstrated that HMGB1 itself has little or no proinflammatory activity, but is able to potentiate inflammatory responses through binding to mediators, such as endotoxin or cytokines. Important questions are to determine the binding partners for HMGB1 in the setting of severe injury and whether inhibition of interactions of HMGB1 and associated molecules with the cell surface can affect outcome after trauma.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1466-609X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1004
pubmed:dateRevised
2010-11-15
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Unraveling the role of high mobility group box protein 1 in severe trauma.
pubmed:affiliation
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA. eabraham@uab.edu
pubmed:publicationType
Journal Article, Comment