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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
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|
pubmed:dateCreated |
1991-3-8
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|
pubmed:abstractText |
We examined the effect of histatin 5 from human parotid saliva on various proteases. Histatin 5 strongly inhibited a trypsin-like protease produced by Bacteroides gingivalis with an IC50 value of 55 nM. Clostripain was also inhibited (IC50 = 800 nM). Activities of other proteases were not affected significantly. Because B. gingivalis is a suspected periodontal pathogen and its proteolytic enzymes have been considered to be associated with periodontal tissue destruction, it is suggested that salivary histatins play a role as a preventive against periodontal disease.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0006-291X
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:day |
31
|
|
pubmed:volume |
174
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
625-30
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
|
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pubmed:year |
1991
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|
pubmed:articleTitle |
Salivary histatin as an inhibitor of a protease produced by the oral bacterium Bacteroides gingivalis.
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|
pubmed:affiliation |
Central Research Division, School of Dentistry, Hokkaido University, Sapporo, Japan.
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pubmed:publicationType |
Journal Article
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