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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1991-3-8
|
| pubmed:abstractText |
The Lens Opacities Case-Control Study evaluated risk factors for age-related nuclear, cortical, posterior subcapsular, and mixed cataracts. The 1380 participants were ophthalmology outpatients, aged 40 to 79 years, classified into the following groups: posterior subcapsular only, 72 patients; nuclear only, 137 patients; cortical only, 290 patients; mixed cataract, 446 patients; and controls, 435 patients. In polychotomous logistic regression analyses, low education increased risk (odds ratio [OR] = 1.46) and regular use of multivitamin supplements decreased risk (OR = 0.63) for all cataract types. Dietary intake of riboflavin, vitamins C, E, and carotene, which have antioxidant potential, was protective for cortical, nuclear, and mixed cataract; intake of niacin, thiamine, and iron also decreased risk. Similar results were found in analyses that combined the antioxidant vitamins (OR = 0.40) or considered the individual nutrients (OR = 0.48 to 0.56). Diabetes increased risk of posterior subcapsular, cortical, and mixed cataracts (OR = 1.56). Oral steroid therapy increased posterior subcapsular cataract risk (OR = 5.83). Females (OR = 1.51) and nonwhites (OR = 2.03) were at increased risk only for cortical cataract. Risk factors for nuclear cataract were a nonprofessional occupation (OR = 1.96), current smoking (OR = 1.68), body mass index (OR = 0.76), and occupational exposure to sunlight (OR = 0.61). Gout medications (OR = 2.48), family history (OR = 1.52), and use of eyeglasses by age 20 years, which is an indicator of myopia (OR = 1.44), increased risk of mixed cataract. The results support a role for the nutritional, medical, personal, and other factors in cataractogenesis. The potentially modifiable factors suggested by this study merit further evaluation.
|
| pubmed:grant | |
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0003-9950
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
109
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
244-51
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:1993036-Adult,
pubmed-meshheading:1993036-Aged,
pubmed-meshheading:1993036-Antioxidants,
pubmed-meshheading:1993036-Case-Control Studies,
pubmed-meshheading:1993036-Cataract,
pubmed-meshheading:1993036-Chi-Square Distribution,
pubmed-meshheading:1993036-Diabetes Mellitus,
pubmed-meshheading:1993036-Diet,
pubmed-meshheading:1993036-Environmental Exposure,
pubmed-meshheading:1993036-Female,
pubmed-meshheading:1993036-Humans,
pubmed-meshheading:1993036-India,
pubmed-meshheading:1993036-Male,
pubmed-meshheading:1993036-Massachusetts,
pubmed-meshheading:1993036-Middle Aged,
pubmed-meshheading:1993036-Odds Ratio,
pubmed-meshheading:1993036-Risk Factors,
pubmed-meshheading:1993036-Socioeconomic Factors,
pubmed-meshheading:1993036-Vitamins
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
The Lens Opacities Case-Control Study. Risk factors for cataract.
|
| pubmed:affiliation |
Department of Preventive Medicine, School of Medicine, State University of New York, Stony Brook 11794-8036.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
|