Linked Life Data

19929921

Source:http://linkedlifedata.com/resource/pubmed/id/19929921

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-5-24
pubmed:abstractText
Available medical therapies against pancreatic cancer are largely ineffective and have many side-effects. Physiologically, vitamins K1 and K2 (VK) act as co-factors for gamma-carboxylation of prothrombin and other coagulation factors. In previous studies, VK analogs have been found to have potent negative effects on the survival of various cancer cells. We hypothesized that the well-tolerated and naturally occurring VK1 and VK2 may be used to inhibit pancreatic cancer cell survival.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1440-1746
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
738-44
pubmed:meshHeading
pubmed-meshheading:19929921-Antineoplastic Agents, pubmed-meshheading:19929921-Apoptosis, pubmed-meshheading:19929921-Caspases, pubmed-meshheading:19929921-Cell Cycle, pubmed-meshheading:19929921-Cell Line, Tumor, pubmed-meshheading:19929921-Cell Survival, pubmed-meshheading:19929921-Cysteine Proteinase Inhibitors, pubmed-meshheading:19929921-Dose-Response Relationship, Drug, pubmed-meshheading:19929921-Extracellular Signal-Regulated MAP Kinases, pubmed-meshheading:19929921-Humans, pubmed-meshheading:19929921-Inhibitory Concentration 50, pubmed-meshheading:19929921-MAP Kinase Kinase 1, pubmed-meshheading:19929921-Pancreatic Neoplasms, pubmed-meshheading:19929921-Phosphorylation, pubmed-meshheading:19929921-Protein Kinase Inhibitors, pubmed-meshheading:19929921-Signal Transduction, pubmed-meshheading:19929921-Time Factors, pubmed-meshheading:19929921-Vitamin K 1, pubmed-meshheading:19929921-Vitamin K 2
pubmed:year
2010
pubmed:articleTitle
Naturally occurring K vitamins inhibit pancreatic cancer cell survival through a caspase-dependent pathway.
pubmed:affiliation
Department of Surgery, Jefferson Center for Pancreatic, Biliary and Related Cancers, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
pubmed:publicationType
Journal Article