Linked Life Data

19929412

Source:http://linkedlifedata.com/resource/pubmed/id/19929412

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2009-11-25
pubmed:abstractText
This Failla Lecture focused on the inter-relationships between tumor angiogenesis, HIF-1 expression and radiotherapy responses. A common thread that bonds all of these factors together is microenvironmental stress caused by reactive oxygen and nitrogen species formed during tumor growth and angiogenesis or in response to cytotoxic treatment. In this review we focus on one aspect of the crossroad between oxidative stress and angiogenesis, namely cycling hypoxia. Understanding of the relative importance of this feature of the tumor microenvironment has recently expanded; it influences tumor biology in ways that are separate from chronic hypoxia. Cycling hypoxia can influence angiogenesis, treatment responses and metastatic behavior. It represents an important and relatively less well understood feature of tumor biology that requires additional research.
pubmed:grant
http://linkedlifedata.com/resource/pubmed/grant/CA40355, http://linkedlifedata.com/resource/pubmed/grant/R01 CA040355-15, http://linkedlifedata.com/resource/pubmed/grant/R01 CA040355-16, http://linkedlifedata.com/resource/pubmed/grant/R01 CA040355-17, http://linkedlifedata.com/resource/pubmed/grant/R01 CA040355-18, http://linkedlifedata.com/resource/pubmed/grant/R01 CA040355-19, http://linkedlifedata.com/resource/pubmed/grant/R01 CA040355-19S1, http://linkedlifedata.com/resource/pubmed/grant/R01 CA040355-20, http://linkedlifedata.com/resource/pubmed/grant/R01 CA040355-21, http://linkedlifedata.com/resource/pubmed/grant/R01 CA040355-22, http://linkedlifedata.com/resource/pubmed/grant/R01 CA040355-23, http://linkedlifedata.com/resource/pubmed/grant/R01 CA040355-24, http://linkedlifedata.com/resource/pubmed/grant/R01 CA040355-25
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1938-5404
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
172
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
653-65
pubmed:dateRevised
2011-3-3
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Relationships between cycling hypoxia, HIF-1, angiogenesis and oxidative stress.
pubmed:affiliation
Radiation Oncology Department, Duke University Medical Center, Durham, Durham, NC 27710, USA. dewhi001@mc.duke.edu
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural