Linked Life Data

19929143

Source:http://linkedlifedata.com/resource/pubmed/id/19929143

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-9-27
pubmed:abstractText
Adipose tissue is an important target for thyroid hormones (TH). However, the metabolism of TH in white adipose tissue is poorly characterized. Our objective was to describe possible changes in activities of TH-metabolizing enzymes in white adipose tissue, and the role of TH metabolism in the tissue during obesogenic treatment, caloric restriction and in response to leptin in mice. Activity of type I iodothyronine 5'-deiodinase (D1) in white fat was stimulated by a high-fat diet, which also increased plasma leptin levels, while brown adipose tissue D1 activity did not change. Caloric restriction decreased the activity of D1 in white fat (but not in the liver), reduced leptin levels, and increased the expression of stearoyl CoA desaturase 1 (SCD-1), a marker and mediator of the effect of leptin on tissue metabolism. Leptin injections increased D1 activity and down-regulated SCD-1 in white fat. Our results demonstrate changes in D1 activity in white adipose tissue under the conditions of changing adiposity, and a stimulatory effect of leptin on D1 activity in the tissue. These results suggest a functional role for D1 in white adipose tissue, with D1 possibly being involved in the control of adipose tissue metabolism and/or accumulation of the tissue.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0862-8408
pubmed:author
pubmed:issnType
Print
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
561-9
pubmed:meshHeading
pubmed-meshheading:19929143-Adipose Tissue, Brown, pubmed-meshheading:19929143-Adipose Tissue, White, pubmed-meshheading:19929143-Animal Nutritional Physiological Phenomena, pubmed-meshheading:19929143-Animals, pubmed-meshheading:19929143-Caloric Restriction, pubmed-meshheading:19929143-Disease Models, Animal, pubmed-meshheading:19929143-Gene Expression Regulation, Enzymologic, pubmed-meshheading:19929143-Injections, Subcutaneous, pubmed-meshheading:19929143-Iodide Peroxidase, pubmed-meshheading:19929143-Leptin, pubmed-meshheading:19929143-Mice, pubmed-meshheading:19929143-Mice, Inbred C57BL, pubmed-meshheading:19929143-Obesity, pubmed-meshheading:19929143-RNA, Messenger, pubmed-meshheading:19929143-Recombinant Proteins, pubmed-meshheading:19929143-Stearoyl-CoA Desaturase, pubmed-meshheading:19929143-Thyroid Hormones
pubmed:year
2010
pubmed:articleTitle
Modulation of type I iodothyronine 5'-deiodinase activity in white adipose tissue by nutrition: possible involvement of leptin.
pubmed:affiliation
Department of Adipose Tissue Biology, Institute of Physiology of the Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't