Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-2-5
pubmed:abstractText
Atherosclerosis is characterized by lipid accumulation in the vessel wall, inflammation, and both macrophage and vascular smooth muscle cell (VSMC) apoptosis. However, whereas VSMC apoptosis in mice with established atherosclerotic plaques or hyperlipidemia increases serum levels of the proatherogenic cytokines monocyte chemotactic protein (MCP)-1, tumor necrosis factor alpha, and interleukin (IL)-6, the link between hyperlipidemia, apoptosis and inflammation, and the mechanisms by which apoptotic cells promote inflammation in atherosclerosis are unknown.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1524-4571
pubmed:author
pubmed:issnType
Electronic
pubmed:day
5
pubmed:volume
106
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
363-72
pubmed:meshHeading
pubmed-meshheading:19926874-Animals, pubmed-meshheading:19926874-Apolipoproteins E, pubmed-meshheading:19926874-Apoptosis, pubmed-meshheading:19926874-Blotting, Western, pubmed-meshheading:19926874-Cells, Cultured, pubmed-meshheading:19926874-Chemokine CCL2, pubmed-meshheading:19926874-Humans, pubmed-meshheading:19926874-Hyperlipidemias, pubmed-meshheading:19926874-Immunohistochemistry, pubmed-meshheading:19926874-Inflammation, pubmed-meshheading:19926874-Intercellular Signaling Peptides and Proteins, pubmed-meshheading:19926874-Interleukin-1alpha, pubmed-meshheading:19926874-Interleukin-6, pubmed-meshheading:19926874-Mice, pubmed-meshheading:19926874-Mice, Knockout, pubmed-meshheading:19926874-Mice, Transgenic, pubmed-meshheading:19926874-Muscle, Smooth, Vascular, pubmed-meshheading:19926874-Myocytes, Smooth Muscle, pubmed-meshheading:19926874-Phagocytosis
pubmed:year
2010
pubmed:articleTitle
Vascular smooth muscle cell apoptosis induces interleukin-1-directed inflammation: effects of hyperlipidemia-mediated inhibition of phagocytosis.
pubmed:affiliation
Division of Cardiovascular Medicine, University of Cambridge, Box 110, ACCI, Addenbrooke's Hospital, Cambridge, CB2 2QQ, UK. mchc2@cam.ac.uk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't