Linked Life Data

19926516

Source:http://linkedlifedata.com/resource/pubmed/id/19926516

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5-6
pubmed:dateCreated
2009-12-2
pubmed:abstractText
The TGF-beta superfamily exhibits a feature making it distinct from many other growth factor families in that the inadequate number of ligands and receptors premises a high degree of promiscuity in ligand-receptor interaction. This highlights the importance of even small differences in affinities and specificities between different binding partners to maintain the broad spectrum of their well defined biological functions. Despite the promiscuous interactions recent data reveal differences in receptor recruitment, architectures of these assemblies and specific modulation by a multitude of extracellular as well as membrane-associated factors. These modulatory mechanisms might possibly add specificity towards defined biological functions despite the overlapping usage of receptors by various ligands.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1879-0305
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
367-77
pubmed:meshHeading
pubmed:articleTitle
Intricacies of BMP receptor assembly.
pubmed:affiliation
Physiologische Chemie II, Theodor-Boveri-Institut für Biowissenschaften der Universität Würzburg, Am Hubland, D-97074 Würzburg, Germany. nickel@biozentrum.uni-wuerzburg.de
pubmed:publicationType
Journal Article, Review