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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1991-3-12
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pubmed:abstractText |
Boron-containing derivatives of 2-thiouracil and 2,4-dithiouracil and the corresponding 6-propyl compounds, containing a dihydroxyboryl group in the 5-position, have been prepared. These compounds accumulate in B16 melanoma in mice in concentrations up to 30 micrograms of boron per gram tissue. The uptake persists. The toxicity of both 2-thiouracil derivatives is low. These compounds are therefore good candidates for boron neutron-capture therapy of malignant melanoma.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-2623
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
315-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1992132-Animals,
pubmed-meshheading:1992132-Boron,
pubmed-meshheading:1992132-Indicators and Reagents,
pubmed-meshheading:1992132-Melanoma, Experimental,
pubmed-meshheading:1992132-Mice,
pubmed-meshheading:1992132-Mice, Inbred C57BL,
pubmed-meshheading:1992132-Molecular Structure,
pubmed-meshheading:1992132-Neutrons,
pubmed-meshheading:1992132-Structure-Activity Relationship,
pubmed-meshheading:1992132-Thiouracil
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pubmed:year |
1991
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pubmed:articleTitle |
Boron-containing thiouracil derivatives for neutron-capture therapy of melanoma.
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pubmed:affiliation |
Department of Chemistry, University of Bremen, Federal Republic of Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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