Source:http://linkedlifedata.com/resource/pubmed/id/19920987
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| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2009-11-20
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| pubmed:abstractText |
Population genetics is the study of allele frequency changes driven by various evolutionary forces such as mutation, natural selection, and random genetic drift. Although natural selection is widely recognized as a bona-fide phenomenon, the extent to which it drives evolution continues to remain unclear and controversial. Various qualitative techniques, or so-called "tests of neutrality", have been introduced to detect signatures of natural selection. A decade and a half ago, Stanley Sawyer and Daniel Hartl provided a mathematical framework, referred to as the Poisson random field (PRF), with which to determine quantitatively the intensity of selection on a particular gene or genomic region. The recent availability of large-scale genetic polymorphism data has sparked widespread interest in genome-wide investigations of natural selection. To that end, the original PRF model is of particular interest for geneticists and evolutionary genomicists. In this article, we will provide a tutorial of the mathematical derivation of the original Sawyer and Hartl PRF model.
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| pubmed:grant | |
| pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19920987-10978302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19920987-11932744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19920987-1459433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19920987-15008412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19920987-15454557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19920987-15545653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19920987-16237444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19920987-16808986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19920987-17072316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19920987-1904993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19920987-7713409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19920987-8001789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19920987-9720272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19920987-9720291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19920987-9872962
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| pubmed:language |
eng
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| pubmed:status |
PubMed-not-MEDLINE
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| pubmed:author | |
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
257864
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| pubmed:dateRevised |
2011-9-26
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| pubmed:articleTitle |
A tutorial of the poisson random field model in population genetics.
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| pubmed:affiliation |
Department of Genetics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
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| pubmed:publicationType |
Journal Article
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