Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-1-26
pubmed:abstractText
Sister chromatid cohesion, crucial for faithful segregation of replicated chromosomes in eukaryotes, is mediated by the multi-subunit protein complex cohesin. The Saccharomyces cerevisiae plasmid 2 micron circle mimics chromosomes in assembling cohesin at its partitioning locus. The plasmid is a multi-copy selfish DNA element that resides in the nucleus and propagates itself stably, presumably with assistance from cohesin. In metaphase cell lysates, or fractions enriched for their cohesed state by sedimentation, plasmid molecules are trapped topologically by the protein ring formed by cohesin. They can be released from cohesin's embrace either by linearizing the DNA or by cleaving a cohesin subunit. Assays using two distinctly tagged cohesin molecules argue against the hand-cuff (an associated pair of monomeric cohesin rings) or the bracelet (a dimeric cohesin ring) model as responsible for establishing plasmid cohesion. Our cumulative results most easily fit a model in which a single monomeric cohesin ring, rather than a series of such rings, conjoins a pair of sister plasmids. These features of plasmid cohesion account for its sister-to-sister mode of segregation by cohesin disassembly during anaphase. The mechanistic similarities of cohesion between mini-chromosome sisters and 2 micron plasmid sisters suggest a potential kinship between the plasmid partitioning locus and centromeres.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-10090726, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-10428036, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-10499801, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-10791970, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-11016957, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-12177044, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-12198550, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-12654244, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-15060134, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-15065662, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-15120997, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-15196892, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-15309048, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-15870297, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-15897179, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-15946764, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-15952899, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-16179255, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-16319193, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-16756491, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-16962805, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-17081975, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-17573771, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-17626884, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-17626885, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-17643378, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-17660750, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-17670945, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-17804787, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-18211850, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-18358805, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-18545699, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-18596691, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-18614046, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-18614053, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-18616427, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-18653893, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-18653894, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-18715997, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-18767966, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-19075111, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-19364922, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-19766562, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-392520, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-8187179, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-9435022, http://linkedlifedata.com/resource/pubmed/commentcorrection/19920123-9990856
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1362-4962
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
570-84
pubmed:dateRevised
2010-9-27
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Yeast cohesin complex embraces 2 micron plasmid sisters in a tri-linked catenane complex.
pubmed:affiliation
School of Biosciences and Bioengineering, IIT Bombay, Powai, Mumbai 400076, India.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural