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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2009-11-20
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pubmed:abstractText |
Increased circulating leptin is present in human heart failure, and leptin deficiency is linked to worse outcomes in chronic ischemic injury. In the present observational study, we tested the hypothesis that cardiac leptin production and signaling are increased in the failing human heart, and that mechanical unloading with a ventricular assist device (VAD) reverses these changes.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AMP-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Leptin,
http://linkedlifedata.com/resource/pubmed/chemical/Natriuretic Peptide, Brain,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Leptin,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/leptin receptor, human
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1941-3297
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
676-83
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:19919993-AMP-Activated Protein Kinases,
pubmed-meshheading:19919993-Female,
pubmed-meshheading:19919993-Heart Failure,
pubmed-meshheading:19919993-Heart-Assist Devices,
pubmed-meshheading:19919993-Humans,
pubmed-meshheading:19919993-Leptin,
pubmed-meshheading:19919993-Male,
pubmed-meshheading:19919993-Middle Aged,
pubmed-meshheading:19919993-Myocardium,
pubmed-meshheading:19919993-Natriuretic Peptide, Brain,
pubmed-meshheading:19919993-Phosphorylation,
pubmed-meshheading:19919993-RNA, Messenger,
pubmed-meshheading:19919993-Receptors, Leptin,
pubmed-meshheading:19919993-STAT3 Transcription Factor,
pubmed-meshheading:19919993-Signal Transduction,
pubmed-meshheading:19919993-Stroke Volume,
pubmed-meshheading:19919993-Treatment Outcome,
pubmed-meshheading:19919993-Tumor Necrosis Factor-alpha,
pubmed-meshheading:19919993-Up-Regulation,
pubmed-meshheading:19919993-Ventricular Function, Left
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pubmed:year |
2009
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pubmed:articleTitle |
Leptin signaling in the failing and mechanically unloaded human heart.
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pubmed:affiliation |
Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. mcgaffinkr@upmc.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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