|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2010-6-22
|
|
pubmed:abstractText |
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease characterised by synovitis and joint destruction. The pathogenesis of RA is not clear, but is considered to be an immune-mediated inflammatory disorder, in which the complement system plays an important role. Although cell-derived microparticles (MPs) have been associated with inflammation and complement activation, it is unknown whether MPs are either cause or consequence. Therefore, we investigated whether circulating MPs differ between patients with very early as yet untreated arthritis and healthy controls, and whether intensive anti-inflammatory treatment of such patients affects circulating MPs.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
1468-2060
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
69
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1378-82
|
|
pubmed:meshHeading |
pubmed-meshheading:19919943-Adult,
pubmed-meshheading:19919943-Antirheumatic Agents,
pubmed-meshheading:19919943-Arthritis, Rheumatoid,
pubmed-meshheading:19919943-Biological Markers,
pubmed-meshheading:19919943-Blood Sedimentation,
pubmed-meshheading:19919943-C-Reactive Protein,
pubmed-meshheading:19919943-Cell-Derived Microparticles,
pubmed-meshheading:19919943-Complement Activation,
pubmed-meshheading:19919943-Complement C1q,
pubmed-meshheading:19919943-Drug Therapy, Combination,
pubmed-meshheading:19919943-Female,
pubmed-meshheading:19919943-Follow-Up Studies,
pubmed-meshheading:19919943-Humans,
pubmed-meshheading:19919943-Inflammation Mediators,
pubmed-meshheading:19919943-Male,
pubmed-meshheading:19919943-Middle Aged,
pubmed-meshheading:19919943-Severity of Illness Index
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Circulating microparticles remain associated with complement activation despite intensive anti-inflammatory therapy in early rheumatoid arthritis.
|
|
pubmed:affiliation |
Correspondence to Dr M T Nurmohamed, Jan van Breemen Institute, Dr Jan van Breemenstraat 2, 1056 AB Amsterdam, The Netherlands. m.nurmohamed@janvanbreemen.nl
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
