|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2010-3-2
|
|
pubmed:abstractText |
p53 Mutations are very common in human hepatocellular carcinoma, and induction of hepatic p53 expression causes lysis of implanted hepatoblastoma cells in a chimeric mouse. Ataxia Telangiectasia Mutated (ATM) kinase senses DNA strand breaks and induces p53. Our aims were to establish whether ATM deficiency alters the carcinogenic response of hepatocytes to diethylnitrosamine (DEN).
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Atr protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Casp3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Cdkn2a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Checkpoint kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Diethylnitrosamine,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Telomerase,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ataxia telangiectasia mutated...
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
1528-0012
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
138
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1155-65.e1-2
|
|
pubmed:dateRevised |
2011-11-2
|
|
pubmed:meshHeading |
pubmed-meshheading:19919837-Animals,
pubmed-meshheading:19919837-Apoptosis,
pubmed-meshheading:19919837-Carcinoma, Hepatocellular,
pubmed-meshheading:19919837-Caspase 3,
pubmed-meshheading:19919837-Cell Aging,
pubmed-meshheading:19919837-Cell Cycle,
pubmed-meshheading:19919837-Cell Cycle Proteins,
pubmed-meshheading:19919837-Cell Transformation, Neoplastic,
pubmed-meshheading:19919837-Chromosome Aberrations,
pubmed-meshheading:19919837-Cyclin-Dependent Kinase Inhibitor p16,
pubmed-meshheading:19919837-DNA-Binding Proteins,
pubmed-meshheading:19919837-Diethylnitrosamine,
pubmed-meshheading:19919837-Disease Models, Animal,
pubmed-meshheading:19919837-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:19919837-Heterozygote,
pubmed-meshheading:19919837-Karyotyping,
pubmed-meshheading:19919837-Liver Neoplasms,
pubmed-meshheading:19919837-Male,
pubmed-meshheading:19919837-Mice,
pubmed-meshheading:19919837-Mice, Knockout,
pubmed-meshheading:19919837-Protein Kinases,
pubmed-meshheading:19919837-Protein-Serine-Threonine Kinases,
pubmed-meshheading:19919837-Signal Transduction,
pubmed-meshheading:19919837-Telomerase,
pubmed-meshheading:19919837-Time Factors,
pubmed-meshheading:19919837-Tumor Suppressor Protein p53,
pubmed-meshheading:19919837-Tumor Suppressor Proteins,
pubmed-meshheading:19919837-Up-Regulation
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Induction of p53 renders ATM-deficient mice refractory to hepatocarcinogenesis.
|
|
pubmed:affiliation |
Australian National University Medical School at The Canberra Hospital, Canberra, Australia.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
