Linked Life Data

19918119

Source:http://linkedlifedata.com/resource/pubmed/id/19918119

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2009-11-17
pubmed:abstractText
The reactive changes in different types of astrocytes were analyzed in parkinsonian syndromes in order to identify common reactions and their relationship to disease severity. Immunohistochemistry was used on formalin-fixed, paraffin-embedded sections from the putamen, pons, and substantia nigra from 13 Parkinson disease (PD), 29 multiple-system atrophy (MSA), 34 progressive supranuclear palsy (PSP), 10 corticobasal degeneration(CBD), and 13 control cases. Classic reactive astrocytes were observed in MSA, PSP, and CBD, but not PD cases; the extent of reactivity correlated with indices of neurodegeneration and disease stage. Approximately 40% to 45% of subcortical astrocytes in PD and PSP accumulated alpha-synuclein and phospho-tau, respectively; subcortical astrocytes in MSA and CBD cases did not accumulate these proteins. Protoplasmic astrocytes were identified from fibrous astrocytes by their expression of parkin coregulated gene and apolipoprotein D, and accumulated abnormal proteins in PD, PSP, and CBD, but not MSA. The increased reactivity of parkin coregulated gene-immunoreactive protoplasmic astrocytes correlated with parkin expression in PSP and CBD. Nonreactive protoplasmic astrocytes were observed in PD and MSA cases; in PD, they accumulated alpha-synuclein, suggesting that the attenuated response might be due to an increase in the level of alpha-synuclein. These heterogeneous astroglial responses in PD, MSA, PSP, and CBD indicate distinct underlying pathogenic mechanisms in each disorder.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-3069
pubmed:author
pubmed:issnType
Print
pubmed:volume
68
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1073-83
pubmed:meshHeading
pubmed-meshheading:19918119-Apolipoproteins D, pubmed-meshheading:19918119-Astrocytes, pubmed-meshheading:19918119-Glycoproteins, pubmed-meshheading:19918119-Humans, pubmed-meshheading:19918119-Immunohistochemistry, pubmed-meshheading:19918119-Membrane Transport Proteins, pubmed-meshheading:19918119-Multiple System Atrophy, pubmed-meshheading:19918119-Nerve Degeneration, pubmed-meshheading:19918119-Parkinson Disease, pubmed-meshheading:19918119-Parkinsonian Disorders, pubmed-meshheading:19918119-Phosphorylation, pubmed-meshheading:19918119-Pons, pubmed-meshheading:19918119-Putamen, pubmed-meshheading:19918119-Severity of Illness Index, pubmed-meshheading:19918119-Substantia Nigra, pubmed-meshheading:19918119-Supranuclear Palsy, Progressive, pubmed-meshheading:19918119-alpha-Synuclein, pubmed-meshheading:19918119-tau Proteins
pubmed:year
2009
pubmed:articleTitle
Degeneration in different parkinsonian syndromes relates to astrocyte type and astrocyte protein expression.
pubmed:affiliation
Prince of Wales Medical Research Institute and the University of New South Wales, Barker Street, Randwick, Sydney, Australia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't