|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2009-11-17
|
|
pubmed:abstractText |
Porcine reproductive and respiratory syndrome (PRRS) causes extensive economic losses in the swine industry. Current strategies and vaccines to control the disease are inadequate. We previously demonstrated that peptide-conjugated phosphorodiamidate morpholino oligomers (PPMOs) could potently inhibit PRRS virus (PRRSV) replication in cell cultures. PPMOs are single-stranded DNA analogues containing a modified backbone and cell-penetrating peptide. PPMOs are nuclease-resistant, water-soluble, can enter cells readily and exhibit highly specific binding to complementary RNA. In this study, we examined PPMO-mediated inhibition of PRRSV replication in a primary culture of porcine pulmonary alveolar macrophages (PAMs).
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1359-6535
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
14
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
899-909
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:19918094-Animals,
pubmed-meshheading:19918094-Caspases,
pubmed-meshheading:19918094-Cell Culture Techniques,
pubmed-meshheading:19918094-Cell Death,
pubmed-meshheading:19918094-Chemokines,
pubmed-meshheading:19918094-Enzyme Induction,
pubmed-meshheading:19918094-Gene Expression Regulation, Viral,
pubmed-meshheading:19918094-Host-Pathogen Interactions,
pubmed-meshheading:19918094-Interferon-beta,
pubmed-meshheading:19918094-Macrophages, Alveolar,
pubmed-meshheading:19918094-Morpholines,
pubmed-meshheading:19918094-Morpholinos,
pubmed-meshheading:19918094-Porcine Reproductive and Respiratory Syndrome,
pubmed-meshheading:19918094-Porcine respiratory and reproductive syndrome virus,
pubmed-meshheading:19918094-Swine,
pubmed-meshheading:19918094-Virus Replication
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Morpholino oligomer-mediated protection of porcine pulmonary alveolar macrophages from arterivirus-induced cell death.
|
|
pubmed:affiliation |
University of Maryland, College Park, MD, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
