Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2009-11-25
pubmed:abstractText
Mucosal vaccination via the respiratory tract can elicit protective immunity in animal infection models, but the underlying mechanisms are still poorly understood. We show that a single intranasal application of the replication-deficient modified vaccinia virus Ankara, which is widely used as a recombinant vaccination vector, results in prominent induction of bronchus-associated lymphoid tissue (BALT). Although initial peribronchiolar infiltrations, characterized by the presence of dendritic cells (DCs) and few lymphocytes, can be found 4 d after virus application, organized lymphoid structures with segregated B and T cell zones are first observed at day 8. After intratracheal application, in vitro-differentiated, antigen-loaded DCs rapidly migrate into preformed BALT and efficiently activate antigen-specific T cells, as revealed by two-photon microscopy. Furthermore, the lung-specific depletion of DCs in mice that express the diphtheria toxin receptor under the control of the CD11c promoter interferes with BALT maintenance. Collectively, these data identify BALT as tertiary lymphoid structures supporting the efficient priming of T cell responses directed against unrelated airborne antigens while crucially requiring DCs for its sustained presence.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19917776-10520991, http://linkedlifedata.com/resource/pubmed/commentcorrection/19917776-10623755, http://linkedlifedata.com/resource/pubmed/commentcorrection/19917776-10859525, http://linkedlifedata.com/resource/pubmed/commentcorrection/19917776-10868279, http://linkedlifedata.com/resource/pubmed/commentcorrection/19917776-12756264, http://linkedlifedata.com/resource/pubmed/commentcorrection/19917776-1438287, http://linkedlifedata.com/resource/pubmed/commentcorrection/19917776-14712275, http://linkedlifedata.com/resource/pubmed/commentcorrection/19917776-15308107, http://linkedlifedata.com/resource/pubmed/commentcorrection/19917776-15311275, http://linkedlifedata.com/resource/pubmed/commentcorrection/19917776-16227213, http://linkedlifedata.com/resource/pubmed/commentcorrection/19917776-16525420, http://linkedlifedata.com/resource/pubmed/commentcorrection/19917776-17082654, http://linkedlifedata.com/resource/pubmed/commentcorrection/19917776-17325198, http://linkedlifedata.com/resource/pubmed/commentcorrection/19917776-17371929, http://linkedlifedata.com/resource/pubmed/commentcorrection/19917776-17404250, http://linkedlifedata.com/resource/pubmed/commentcorrection/19917776-18270165, http://linkedlifedata.com/resource/pubmed/commentcorrection/19917776-18412969, http://linkedlifedata.com/resource/pubmed/commentcorrection/19917776-18816482, http://linkedlifedata.com/resource/pubmed/commentcorrection/19917776-18825750, http://linkedlifedata.com/resource/pubmed/commentcorrection/19917776-19129447, http://linkedlifedata.com/resource/pubmed/commentcorrection/19917776-19234150, http://linkedlifedata.com/resource/pubmed/commentcorrection/19917776-19454682, http://linkedlifedata.com/resource/pubmed/commentcorrection/19917776-2033387, http://linkedlifedata.com/resource/pubmed/commentcorrection/19917776-2663024, http://linkedlifedata.com/resource/pubmed/commentcorrection/19917776-6332522, http://linkedlifedata.com/resource/pubmed/commentcorrection/19917776-9175875
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1540-9538
pubmed:author
pubmed:issnType
Electronic
pubmed:day
23
pubmed:volume
206
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2593-601
pubmed:dateRevised
2010-9-27
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Induced bronchus-associated lymphoid tissue serves as a general priming site for T cells and is maintained by dendritic cells.
pubmed:affiliation
Institute of Immunology, Hannover Medical School, 30625 Hannover, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't