Linked Life Data

19917682

Source:http://linkedlifedata.com/resource/pubmed/id/19917682

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2009-11-20
pubmed:abstractText
MARCH-I (membrane-associated RING-CH I) has been suggested as a physiological E3 ubiquitin ligase for both MHC class II (MHC II) and B7-2. In this study, we show that MARCH-I-mediated MHC II ubiquitination is necessary for the maintenance of conventional dendritic cell (cDC) functions in the steady state. MARCH-I-deficient cDCs accumulated MHC II and B7-2 and exhibited low Ag-presenting ability for exogenous Ags and low cytokine-producing ability upon stimulation in vivo. Importantly, MHC II, but not B7-2, was required for impaired cDC function induced by loss of MARCH-I in vivo. Moreover, MHC II knockin mice whose MHC II was not ubiquitinated showed dysfunction of cDC similar to that of MARCH-I knockout mice. These results suggest that the accumulation of MHC II resulting from loss of ubiquitination caused cDC abnormality; therefore, MARCH-I may function as a housekeeper of cDC in the steady state.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1550-6606
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
183
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6893-7
pubmed:meshHeading
pubmed-meshheading:19917682-Animals, pubmed-meshheading:19917682-Antigen Presentation, pubmed-meshheading:19917682-Antigens, CD4, pubmed-meshheading:19917682-Antigens, CD8, pubmed-meshheading:19917682-Antigens, CD86, pubmed-meshheading:19917682-Dendritic Cells, pubmed-meshheading:19917682-Flow Cytometry, pubmed-meshheading:19917682-Gene Expression, pubmed-meshheading:19917682-Gene Expression Regulation, pubmed-meshheading:19917682-Gene Knock-In Techniques, pubmed-meshheading:19917682-Genes, MHC Class II, pubmed-meshheading:19917682-Histocompatibility Antigens Class II, pubmed-meshheading:19917682-Mice, pubmed-meshheading:19917682-Mice, Inbred C57BL, pubmed-meshheading:19917682-Mice, Knockout, pubmed-meshheading:19917682-Ubiquitin-Protein Ligases, pubmed-meshheading:19917682-Ubiquitination
pubmed:year
2009
pubmed:articleTitle
Cutting edge: requirement of MARCH-I-mediated MHC II ubiquitination for the maintenance of conventional dendritic cells.
pubmed:affiliation
Laboratory for Infectious Immunity, RIKENResearch Center for Allergy and Immunology, Tsurumi-ku, Yokohama, Kanagawa, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't