Linked Life Data

19917302

Source:http://linkedlifedata.com/resource/pubmed/id/19917302

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2010-3-16
pubmed:abstractText
Cystatin C is a strong inhibitor of cysteine proteinases expressed by diverse cells. Variant B cystatin C, which was associated with increased risk of developing age-related macular degeneration, differs from the wild type protein by a single amino acid (A25T) in the signal sequence responsible for its targeting to the secretory pathway. The same variant conveys susceptibility to Alzheimer disease. Our investigations of the trafficking and processing of variant B cystatin C in living RPE cells highlight impaired secretion of extracellular modulators and inappropriate protein retention in RPE cells as potential molecular mechanisms underpinning macular, and possibly neuronal, degeneration.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1878-5646
pubmed:author
pubmed:copyrightInfo
Copyright 2009 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
31
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
737-42
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Cystatin C in macular and neuronal degenerations: implications for mechanism(s) of age-related macular degeneration.
pubmed:affiliation
Unit of Ophthalmology, School of Clinical Sciences, Liverpool L69 3GA, UK. luminita.paraoan@liverpool.ac.uk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't