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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2009-12-16
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pubmed:abstractText |
The association between torcetrapib and its off-target effects on blood pressure suggested a possible class-specific effect. The effects of dalcetrapib (RO4607381/JTT-705) and torcetrapib on haemodynamics and the renin-angiotensin-aldosterone system (RAAS) were therefore assessed in a rat model.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1476-5381
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
158
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1763-70
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pubmed:dateRevised |
2011-3-3
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pubmed:meshHeading |
pubmed-meshheading:19917065-Adrenal Glands,
pubmed-meshheading:19917065-Animals,
pubmed-meshheading:19917065-Anticholesteremic Agents,
pubmed-meshheading:19917065-Aorta,
pubmed-meshheading:19917065-Blood Pressure,
pubmed-meshheading:19917065-Cholesterol Ester Transfer Proteins,
pubmed-meshheading:19917065-Dose-Response Relationship, Drug,
pubmed-meshheading:19917065-Heart Rate,
pubmed-meshheading:19917065-Hemodynamics,
pubmed-meshheading:19917065-Male,
pubmed-meshheading:19917065-Polymerase Chain Reaction,
pubmed-meshheading:19917065-Quinolines,
pubmed-meshheading:19917065-RNA, Messenger,
pubmed-meshheading:19917065-Rats,
pubmed-meshheading:19917065-Rats, Inbred SHR,
pubmed-meshheading:19917065-Rats, Wistar,
pubmed-meshheading:19917065-Renin-Angiotensin System,
pubmed-meshheading:19917065-Sulfhydryl Compounds
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pubmed:year |
2009
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pubmed:articleTitle |
Dalcetrapib: no off-target toxicity on blood pressure or on genes related to the renin-angiotensin-aldosterone system in rats.
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pubmed:affiliation |
Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands. e.s.stroes@amc.uva.nl
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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