|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2010-4-28
|
|
pubmed:abstractText |
A large number of studies point toward chronic aspiration associated with gastroesophageal reflux disease (GERD) as an important factor involved in the development of asthma, the incidence of which has increased dramatically in industrially developed countries. Recent work suggests that medical intervention aimed at acid blockade is not sufficient to relieve the effects of chronic aspiration on asthma pathology, leaving surgical treatment of the disease as one of the few remaining options. This study examined the effect of chronic aspiration on the airway-associated immune response to allergens using a model of experimentally induced airway hypersensitivity in Balb/c mice.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
1432-2218
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
24
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1066-74
|
|
pubmed:meshHeading |
pubmed-meshheading:19915914-Animals,
pubmed-meshheading:19915914-Asthma,
pubmed-meshheading:19915914-Disease Models, Animal,
pubmed-meshheading:19915914-Disease Progression,
pubmed-meshheading:19915914-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:19915914-Follow-Up Studies,
pubmed-meshheading:19915914-Gastric Acid,
pubmed-meshheading:19915914-Gastroesophageal Reflux,
pubmed-meshheading:19915914-Immunity, Cellular,
pubmed-meshheading:19915914-Interleukin-12,
pubmed-meshheading:19915914-Interleukin-5,
pubmed-meshheading:19915914-Lung,
pubmed-meshheading:19915914-Macrophages, Alveolar,
pubmed-meshheading:19915914-Male,
pubmed-meshheading:19915914-Mice,
pubmed-meshheading:19915914-Mice, Inbred BALB C,
pubmed-meshheading:19915914-T-Lymphocytes,
pubmed-meshheading:19915914-Tumor Necrosis Factor-alpha
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Gastroesophageal reflux-associated aspiration alters the immune response in asthma.
|
|
pubmed:affiliation |
Department of Surgery, Duke University Medical Center, DUMC Box 2605, Durham, NC 27710, USA.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
