|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
22
|
|
pubmed:dateCreated |
2009-11-16
|
|
pubmed:abstractText |
We describe a case of systemic mastocytosis associated with myelodysplastic syndrome. The bone marrow showed multifocal clusters of mast cells and myeloid dysplasia. Sequencing of the KIT DNA revealed a point mutation at codon 816 including a substitution of valine for aspartic acid (D816V). The patient's tumor did not respond to imatinib; however, interferon-alpha reduced the bone marrow mast cells and serum total tryptase. The patient remains alive at one year after the diagnosis without disease progression.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1349-7235
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
48
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1973-8
|
|
pubmed:meshHeading |
pubmed-meshheading:19915299-Bone Marrow,
pubmed-meshheading:19915299-Drug Resistance,
pubmed-meshheading:19915299-Female,
pubmed-meshheading:19915299-Humans,
pubmed-meshheading:19915299-Interferon-alpha,
pubmed-meshheading:19915299-Mast Cells,
pubmed-meshheading:19915299-Mastocytosis, Systemic,
pubmed-meshheading:19915299-Middle Aged,
pubmed-meshheading:19915299-Myelodysplastic Syndromes,
pubmed-meshheading:19915299-Piperazines,
pubmed-meshheading:19915299-Point Mutation,
pubmed-meshheading:19915299-Proto-Oncogene Proteins c-kit,
pubmed-meshheading:19915299-Pyrimidines
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Successful treatment of KIT D816V-positive, imatinib-resistant systemic mastocytosis with interferon-alpha.
|
|
pubmed:affiliation |
Division of Hematology, Department of Internal Medicine, National Hospital Organization Minami-Okayama Medical Center, Okayama. yoshidac@s-okayama.hosp.go.jp
|
|
pubmed:publicationType |
Journal Article,
Case Reports
|
