Source:http://linkedlifedata.com/resource/pubmed/id/19914667
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
2010-4-19
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pubmed:abstractText |
Apolipoprotein B to A-1 (apo B/A-1) ratio is reportedly a better predictor of atherosclerotic vascular disease than low-density lipoprotein cholesterol (LDL-C). The aim of this study was to assess the association of serum apo B/A-1 ratio with insulin resistance and adiponectin in patients with different grades of glucose intolerance. Patients were divided according to glucose tolerance into 3 groups: normal glucose tolerance without metabolic syndrome (n = 229), impaired fasting glucose (subjects with fasting plasma glucose level between 100 and 125 mg/dL, n = 658), and type 2 diabetes mellitus (n = 381). Serum concentrations of apo B, apo A-1, glucose, total cholesterol (TC), triglycerides, and high-density lipoprotein cholesterol (HDL-C) and adiponectin were measured. Insulin resistance was estimated by the homeostasis model assessment of insulin resistance index (HOMA-IR). There were significant differences in metabolic parameters among the groups, including waist circumference, insulin, HOMA-IR, and apo B/A-1 ratio, which increased sequentially with glucose intolerance, whereas adiponectin level decreased with increasing severity of glucose intolerance. The apo B/A-1 ratio was significantly correlated with TC, triglycerides, LDL-C, HDL-C, adiponectin, and HOMA-IR in normal glucose tolerance, impaired fasting glucose, and type 2 diabetes mellitus. Multiple regression analysis showed that apo B/A-1 ratio was significantly associated with TC, LDL-C, HDL-C, and adiponectin. In conclusion, apo B/A-1 ratio was significantly associated with insulin resistance according to glucose intolerance; and serum adiponectin was an important independent factor associated with apo B/A-1 ratio in Koreans.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adiponectin,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoprotein A-I,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins B,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1532-8600
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pubmed:author |
pubmed-author:AhnChul WooCW,
pubmed-author:ChaBong SooBS,
pubmed-author:ChoMin HoMH,
pubmed-author:JeeSun HaSH,
pubmed-author:KimKyung RaeKR,
pubmed-author:LeeEun JigEJ,
pubmed-author:LeeHyun ChulHC,
pubmed-author:LeeYoon BumYB,
pubmed-author:LimSung KilSK,
pubmed-author:NamJi SunJS,
pubmed-author:ParkJong SukJS,
pubmed-author:RohJung MinJM,
pubmed-author:YooJeong SeonJS
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pubmed:issnType |
Electronic
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
677-82
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pubmed:meshHeading |
pubmed-meshheading:19914667-Adiponectin,
pubmed-meshheading:19914667-Adult,
pubmed-meshheading:19914667-Aged,
pubmed-meshheading:19914667-Apolipoprotein A-I,
pubmed-meshheading:19914667-Apolipoproteins B,
pubmed-meshheading:19914667-Cholesterol,
pubmed-meshheading:19914667-Cross-Sectional Studies,
pubmed-meshheading:19914667-Glucose Intolerance,
pubmed-meshheading:19914667-Humans,
pubmed-meshheading:19914667-Insulin Resistance,
pubmed-meshheading:19914667-Korea,
pubmed-meshheading:19914667-Linear Models,
pubmed-meshheading:19914667-Middle Aged,
pubmed-meshheading:19914667-Multivariate Analysis,
pubmed-meshheading:19914667-Triglycerides
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pubmed:year |
2010
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pubmed:articleTitle |
Adiponectin is independently associated with apolipoprotein B to A-1 ratio in Koreans.
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pubmed:affiliation |
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
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