Linked Life Data

19913852

Source:http://linkedlifedata.com/resource/pubmed/id/19913852

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-3-22
pubmed:abstractText
The aim was to evaluate the possible role of tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), C-reactive protein (CRP), low fitness, and fatness in the early development of clustering of cardiovascular disease (CVD) risk factors and insulin resistance. Subjects for this cross-sectional study were obtained from 18 schools near Copenhagen, Denmark. Two hundred ten 9-year-old children were selected for cytokine analysis from 434 third-grade children with complete CVD risk profiles. The subgroup was selected according to the CVD risk factor profile (upper and lower quartile of a composite CVD risk score). All the CVD risk factors and CRP differed between the high- and low-risk groups; but plasma glucose, TNF-alpha, and IL-6 had small and inconsistent differences. Strong associations were found between CVD risk scores and fitness (VO(2peak)) or fatness. No associations were found between CVD risk scores and TNF-alpha and IL-6. C-reactive protein was associated with fitness, fatness, and CVD risk score. This study does not support an association between plasma IL-6 or TNF-alpha and low insulin sensitivity or clustering of CVD risk factors in a young cohort. Inflammation was more pronounced in fat and unfit children based on the association with CRP levels. The association between fitness and fatness variables, insulin resistance, and clustered risk could be caused by other mechanisms related to these exposures. The role of IL-6 remains unclear.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1532-8600
pubmed:author
pubmed:copyrightInfo
Copyright 2010 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
561-6
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Cytokines and clustered cardiovascular risk factors in children.
pubmed:affiliation
Center for Research in Childhood Health, Institute of Sport Science and Clinical Biomechanics, University of Southern Denmark, DK-5230 Odense, Denmark. lboandersen@health.sdu.dk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't