Source:http://linkedlifedata.com/resource/pubmed/id/19913849
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2010-5-24
|
| pubmed:abstractText |
The aim of the study was to look at the association of angiopoietin-2 (Ang-2) in Asian Indian subjects with different grades of glucose intolerance and in those with hypertension and metabolic syndrome (MS). Three groups were recruited from the Chennai Urban Rural Epidemiology Study, a population-based study in southern India, as follows: group 1, normal glucose tolerance(n = 45); group 2, impaired glucose tolerance (IGT) (n = 45); and group 3, type 2 diabetes mellitus (T2DM) (n = 40). Angiopoietin-2 was estimated by enzyme-linked immunosorbent assay. Hypertension was diagnosed based on medical history, drug treatment of hypertension, and/or if the subjects had systolic blood pressure at least 130 mm Hg and/or diastolic blood pressure at least 85 mm Hg. Metabolic syndrome was defined using modified National Cholesterol Education Program-Adult Treatment Panel III guidelines. Subjects with T2DM had higher age-adjusted Ang-2 values (3741 +/- 1429 pg/mL) compared with subjects with IGT (1907 +/- 855 pg/mL) and normal glucose tolerance (1462 +/- 856 pg/mL) (P for trend < .001). Regression analysis showed that there was a linear increase in mean Ang-2 values with increasing severity of glucose intolerance, even after adjusting for age, sex, and body mass index. Angiopoietin-2 levels were also elevated in subjects with hypertension (P = .004) and in subjects with MS even in the absence of fasting hyperglycemia (P = .011). There was also a linear increase in the mean values of Ang-2 with increase in number of components of MS (P for trend < .001). This study demonstrates that increased levels of Ang-2 are seen in Asian Indian subjects with IGT, T2DM, and hypertension and in subjects with MS even in the absence of fasting hyperglycemia.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
1532-8600
|
| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2010 Elsevier Inc. All rights reserved.
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
59
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
774-9
|
| pubmed:meshHeading |
pubmed-meshheading:19913849-Adult,
pubmed-meshheading:19913849-Age Factors,
pubmed-meshheading:19913849-Angiopoietin-2,
pubmed-meshheading:19913849-Anthropometry,
pubmed-meshheading:19913849-Diabetes Mellitus, Type 2,
pubmed-meshheading:19913849-Female,
pubmed-meshheading:19913849-Glucose Intolerance,
pubmed-meshheading:19913849-Glucose Tolerance Test,
pubmed-meshheading:19913849-Humans,
pubmed-meshheading:19913849-Hypercholesterolemia,
pubmed-meshheading:19913849-Hypertension,
pubmed-meshheading:19913849-India,
pubmed-meshheading:19913849-Male,
pubmed-meshheading:19913849-Metabolic Syndrome X,
pubmed-meshheading:19913849-Middle Aged,
pubmed-meshheading:19913849-Regression Analysis,
pubmed-meshheading:19913849-Risk Factors,
pubmed-meshheading:19913849-Rural Population,
pubmed-meshheading:19913849-Urban Population
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Angiopoietin-2 levels in glucose intolerance, hypertension, and metabolic syndrome in Asian Indians (Chennai Urban Rural Epidemiology Study-74).
|
| pubmed:affiliation |
Madras Diabetes Research Foundation & Dr Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control, Gopalapuram, Chennai 600086, India.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|