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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-1-27
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pubmed:abstractText |
Interleukin-11 (IL-11) is an anti-apoptotic, anti-inflammatory cytokine with hematopoietic potential. The expression and protective actions of IL-11 have not been explored in the eye. The expression of IL-11 in primary cultures of human retinal pigment epithelial (HRPE) and human corneal fibroblast (HCRF) cells were evaluated in these studies. Constitutive secretion of IL-11 was not observed in either HRPE or HCRF. TNF-alpha+IL-1 induced IL-11 secretion and this production was inhibited by NFkappaB pathway inhibitors. IFN-gamma significantly inhibited TNF-alpha and IL-1 induced IL-11 secretion and inhibitors of JAK-STAT pathway reversed this inhibition. TGF-beta induced IL-11 secretion that was blocked by TGF-beta receptor 1 inhibitor but not by IFN-gamma. RT-PCR analysis confirmed the effects of IL-1, TNF-alpha, IFN-gamma and TGF-beta on IL-11 secretion at mRNA levels. Our results demonstrate that IL-11 is dramatically up regulated in retina and cornea cells and that IFN-gamma is a physiological inhibitor of IL-11 expression.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19913506-10407498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19913506-10614683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19913506-12745003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19913506-12760902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19913506-1386338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19913506-14525967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19913506-14734714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19913506-15368539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19913506-15987797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19913506-17013806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19913506-17122042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19913506-17325843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19913506-17629706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19913506-18322185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19913506-18401155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19913506-18639520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19913506-19664109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19913506-2145578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19913506-8071352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19913506-8133053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19913506-8556503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19913506-8871663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19913506-9166826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19913506-9649564
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1090-2104
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2009. Published by Elsevier Inc.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
391
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
287-92
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pubmed:dateRevised |
2011-7-19
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pubmed:meshHeading |
pubmed-meshheading:19913506-Cell Line,
pubmed-meshheading:19913506-Cornea,
pubmed-meshheading:19913506-Gene Expression Regulation,
pubmed-meshheading:19913506-Humans,
pubmed-meshheading:19913506-Interferon-gamma,
pubmed-meshheading:19913506-Interleukin-1,
pubmed-meshheading:19913506-Interleukin-11,
pubmed-meshheading:19913506-Janus Kinases,
pubmed-meshheading:19913506-NF-kappa B,
pubmed-meshheading:19913506-Retina,
pubmed-meshheading:19913506-STAT Transcription Factors,
pubmed-meshheading:19913506-Tumor Necrosis Factor-alpha
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pubmed:year |
2010
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pubmed:articleTitle |
IL-11 expression in retinal and corneal cells is regulated by interferon-gamma.
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pubmed:affiliation |
Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, United States.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Intramural
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