Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2009-11-30
pubmed:abstractText
Changes in gene expression directed by transcriptional regulators can give rise to new phenotypes. While gene expression profiles can be maintained across large evolutionary distances, transcription factor-DNA interactions diverge rapidly. The application of new genome-wide methodologies has begun refining our global understanding of when and where mammalian transcription factors interact with DNA, thereby providing new insight into the mechanisms of transcriptional evolution. The interplay between cis and trans regulation of gene expression is an increasingly active area of investigation, and recent studies suggest that mutations in cis-regulatory DNA can explain many inter-species differences in gene expression.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1879-0380
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
579-85
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Evolution of transcriptional control in mammals.
pubmed:affiliation
Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't