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pubmed-article:19912226pubmed:abstractTextAlthough exogenous nitric oxide (NO) clearly modifies platelet function, the role and the source of endogenous NO in vivo remain undefined. In addition, endothelial NO synthase (NOS-3) critically regulates vessel tone but its role in modulating platelet function is unclear. In this paper we have investigated the roles of endogenous NO and NOS-3 in regulating platelet function in vivo and determined the functional contribution made by platelet-derived NO.lld:pubmed
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pubmed-article:19912226pubmed:dateRevised2011-3-3lld:pubmed
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pubmed-article:19912226pubmed:articleTitlePlatelet aggregation responses are critically regulated in vivo by endogenous nitric oxide but not by endothelial nitric oxide synthase.lld:pubmed
pubmed-article:19912226pubmed:affiliationMolecular Medicine Section, National Heart and Lung Institute, Imperial College London, London, UK.lld:pubmed
pubmed-article:19912226pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19912226pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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