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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2009-12-16
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pubmed:abstractText |
Although exogenous nitric oxide (NO) clearly modifies platelet function, the role and the source of endogenous NO in vivo remain undefined. In addition, endothelial NO synthase (NOS-3) critically regulates vessel tone but its role in modulating platelet function is unclear. In this paper we have investigated the roles of endogenous NO and NOS-3 in regulating platelet function in vivo and determined the functional contribution made by platelet-derived NO.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1476-5381
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
158
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1735-42
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pubmed:dateRevised |
2011-3-3
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pubmed:meshHeading |
pubmed-meshheading:19912226-Animals,
pubmed-meshheading:19912226-Endothelium, Vascular,
pubmed-meshheading:19912226-Enzyme Inhibitors,
pubmed-meshheading:19912226-Female,
pubmed-meshheading:19912226-Humans,
pubmed-meshheading:19912226-Male,
pubmed-meshheading:19912226-Mice,
pubmed-meshheading:19912226-Mice, Inbred BALB C,
pubmed-meshheading:19912226-Mice, Knockout,
pubmed-meshheading:19912226-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:19912226-Nitric Oxide,
pubmed-meshheading:19912226-Nitric Oxide Synthase Type III,
pubmed-meshheading:19912226-Platelet Aggregation,
pubmed-meshheading:19912226-Platelet Function Tests,
pubmed-meshheading:19912226-Thrombin
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pubmed:year |
2009
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pubmed:articleTitle |
Platelet aggregation responses are critically regulated in vivo by endogenous nitric oxide but not by endothelial nitric oxide synthase.
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pubmed:affiliation |
Molecular Medicine Section, National Heart and Lung Institute, Imperial College London, London, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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