Linked Life Data

1991046

Source:http://linkedlifedata.com/resource/pubmed/id/1991046

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-3-8
pubmed:abstractText
We provide here a list of 154 P450 genes and seven putative pseudogenes that have been characterized as of October 20, 1990. These genes have been described in a total of 23 eukaryotes (including nine mammalian and one plant species) and six prokaryotes. Of 27 gene families so far described, 10 exist in all mammals. These 10 families comprise 18 subfamilies, of which 16 and 14 have been mapped in the human and mouse genomes, respectively; to date, each subfamily appears to represent a cluster of tightly linked genes. We propose here a modest revision of the initially proposed (Nebert et al., DNA 6, 1-11, 1987) and updated (Nebert et al., DNA 8, 1-13, 1989) nomenclature system based on evolution of the superfamily. For the gene we recommend that the italicized root symbol CYP for human (Cyp for mouse), representing cytochrome P450, be followed by an Arabic number denoting the family, a letter designating the subfamily (when two or more exist), and an Arabic numeral representing the individual gene within the subfamily. A hyphen should precede the final number in mouse genes. We suggest that the human nomenclature system be used for other species. This system is consistent with our earlier proposed nomenclature for P450 of all eukaryotes and prokaryotes, except that we are discouraging the future use of cumbersome Roman numerals.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1044-5498
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:geneSymbol
CYP1, CYP11, CYP17, CYP19, CYP2, CYP21, CYP27, CYP3, CYP4, Cyp-17, Cyp-19, Cyp-21, Cyp-27
pubmed:owner
NLM
pubmed:authorsComplete
N
pubmed:pagination
1-14
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:articleTitle
The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature.
pubmed:affiliation
Department of Environmental Health, University of Cincinnati Medical Center, OH 45267-0056.
pubmed:publicationType
Journal Article, Review