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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-3-2
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pubmed:abstractText |
One of the challenges to treating inflammatory bowel disease (IBD) is to target the site of inflammation. We engineered nanoparticles (NPs) to deliver an anti-inflammatory tripeptide Lys-Pro-Val (KPV) to the colon and assessed its therapeutic efficacy in a mouse model of colitis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alginates,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Chitosan,
http://linkedlifedata.com/resource/pubmed/chemical/Dextran Sulfate,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Carriers,
http://linkedlifedata.com/resource/pubmed/chemical/Gastrointestinal Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Glucuronic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Hexuronic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrogels,
http://linkedlifedata.com/resource/pubmed/chemical/MSH (11-13),
http://linkedlifedata.com/resource/pubmed/chemical/Melanocyte-Stimulating Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Polysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/alginic acid
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1528-0012
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
138
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
843-53.e1-2
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pubmed:dateRevised |
2010-9-23
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pubmed:meshHeading |
pubmed-meshheading:19909746-Administration, Oral,
pubmed-meshheading:19909746-Alginates,
pubmed-meshheading:19909746-Animals,
pubmed-meshheading:19909746-Anti-Inflammatory Agents,
pubmed-meshheading:19909746-Caco-2 Cells,
pubmed-meshheading:19909746-Chemistry, Pharmaceutical,
pubmed-meshheading:19909746-Chitosan,
pubmed-meshheading:19909746-Colitis,
pubmed-meshheading:19909746-Colon,
pubmed-meshheading:19909746-Dextran Sulfate,
pubmed-meshheading:19909746-Disease Models, Animal,
pubmed-meshheading:19909746-Dose-Response Relationship, Drug,
pubmed-meshheading:19909746-Drug Carriers,
pubmed-meshheading:19909746-Drug Compounding,
pubmed-meshheading:19909746-Female,
pubmed-meshheading:19909746-Gastrointestinal Agents,
pubmed-meshheading:19909746-Glucuronic Acid,
pubmed-meshheading:19909746-Hexuronic Acids,
pubmed-meshheading:19909746-Humans,
pubmed-meshheading:19909746-Hydrogels,
pubmed-meshheading:19909746-Intestinal Mucosa,
pubmed-meshheading:19909746-Melanocyte-Stimulating Hormones,
pubmed-meshheading:19909746-Mice,
pubmed-meshheading:19909746-Mice, Inbred C57BL,
pubmed-meshheading:19909746-Nanoparticles,
pubmed-meshheading:19909746-Peptide Fragments,
pubmed-meshheading:19909746-Polysaccharides,
pubmed-meshheading:19909746-Solubility,
pubmed-meshheading:19909746-Time Factors
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pubmed:year |
2010
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pubmed:articleTitle |
Drug-loaded nanoparticles targeted to the colon with polysaccharide hydrogel reduce colitis in a mouse model.
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pubmed:affiliation |
Division of Digestive Diseases, Department of Medicine, Emory University, Atlanta, Georgia 30322, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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