Linked Life Data

19908587

Source:http://linkedlifedata.com/resource/pubmed/id/19908587

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2009-11-13
pubmed:abstractText
A series of mesostructured Mn-MCM-41 composites were synthesized via a co-assembly route with tetraethylorthosilicate (TEOS) and manganese sulfate (MnSO4) as silica and manganese sources, respectively. And a model drug of cephanone was introduced via physical adsorption process into the channels of mesoporous silica, which could be used as the Mn-MCM-41 type mesoporous silica-based drug controlled-release delivery system. XRD, TEM, FT-IR, EDS and N2 adsorption-desorption were used to characterize the structural and textural properties of Mn-MCM-41 composites. The investigations showed that the addition of a small amount of manganese species was favorable for the long-range ordered structure of the mesoporous composites, whereas the ordered mesostructure was partially or completely distorted when the loaded manganese increased. The characterizations of cephanone loaded Mn-MCM-41 and in vitro release studies showed that the in vitro releases of cephanone in the ordered mesoporous materials follow an anomalous non-Fick's transport, and the impregnated manganese species had great influences on the release rate of cephanone from mesopores.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1533-4880
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6700-9
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Synthesis of surface modified mesoporous materials via co-assemble route and their drug release properties.
pubmed:affiliation
School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225002, Jiangsu, PR China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't