| pubmed-article:19906968 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19906968 | lifeskim:mentions | umls-concept:C0031760 | lld:lifeskim |
| pubmed-article:19906968 | lifeskim:mentions | umls-concept:C0026046 | lld:lifeskim |
| pubmed-article:19906968 | lifeskim:mentions | umls-concept:C0058836 | lld:lifeskim |
| pubmed-article:19906968 | lifeskim:mentions | umls-concept:C0013138 | lld:lifeskim |
| pubmed-article:19906968 | lifeskim:mentions | umls-concept:C0376451 | lld:lifeskim |
| pubmed-article:19906968 | pubmed:issue | 45 | lld:pubmed |
| pubmed-article:19906968 | pubmed:dateCreated | 2009-11-12 | lld:pubmed |
| pubmed-article:19906968 | pubmed:abstractText | shibire(ts1), a temperature-sensitive mutation of the Drosophila gene encoding a Dynamin orthologue, blocks vesicle endocytosis and thus synaptic transmission, at elevated, or restrictive temperatures. By targeted Gal4 expression, UAS-shibire(ts1) has been used to dissect neuronal circuits. We investigated the effects of UAS-shibire(ts1) overexpression in Drosophila photoreceptors at permissive (19 degrees C) and restrictive (31 degrees C) temperatures. At 19 degrees C, overexpression of UAS-shi(ts1) causes decelerated phototransduction and reduced neurotransmitter release. This phenotype is exacerbated with dark adaptation, age and in white mutants. Photoreceptors overexpressing UAS-shibire(ts1) contain terminals with widespread vacuolated mitochondria, reduced numbers of vesicles and bundled microtubules. Immuno-electron microscopy reveals that the latter are dynamin coated. Further, the microtubule phenotype is not restricted to photoreceptors, as UAS-shibire(ts1) overexpression in lamina cells also bundles microtubules. We conclude that dynamin has multiple functions that are interrupted by UAS-shibire(ts1) overexpression in Drosophila photoreceptors, destabilizing their neural communication irreversibly at previously reported permissive temperatures. | lld:pubmed |
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| pubmed-article:19906968 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19906968 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19906968 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19906968 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19906968 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19906968 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:19906968 | pubmed:issn | 1529-2401 | lld:pubmed |
| pubmed-article:19906968 | pubmed:author | pubmed-author:Meinertzhagen... | lld:pubmed |
| pubmed-article:19906968 | pubmed:author | pubmed-author:JuusolaMikkoM | lld:pubmed |
| pubmed-article:19906968 | pubmed:author | pubmed-author:WardillTrevor... | lld:pubmed |
| pubmed-article:19906968 | pubmed:author | pubmed-author:Gonzalez-Bell... | lld:pubmed |
| pubmed-article:19906968 | pubmed:author | pubmed-author:KostylevaRips... | lld:pubmed |
| pubmed-article:19906968 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19906968 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:19906968 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:19906968 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19906968 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19906968 | pubmed:pagination | 14199-210 | lld:pubmed |
| pubmed-article:19906968 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
| pubmed-article:19906968 | pubmed:meshHeading | pubmed-meshheading:19906968... | lld:pubmed |
