Source:http://linkedlifedata.com/resource/pubmed/id/19906510
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2010-2-3
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| pubmed:abstractText |
Expression of Id-1 (inhibitors of DNA binding/differentiation protein 1) and TSP-1 (thrombospondin-1) in mucoepidermoid carcinoma and their relationship to pathological features and prognosis was studied. Moderately and poorly differentiated groups had significantly higher Id-1 positive expression rate (p<0.05) than well differentiated carcinoma. Stages III-IV showed significant increase of Id-1 positive expression rate (p<0.05) compared with stages I and II. Id-1 positive expression was significantly higher in patients with cervical lymph node metastasis or relapse at 5 years (p<0.05). After that, patients with negative Id-1 expression had significantly higher tumor-free survival than patients with positive expression (p<0.05). Correlation between the expression of Id-1 and TSP-1 in mucoepidermoid carcinoma was negative (p<0.05). Poorly differentiated groups show significantly lower TSP-1 positive expression rate than well differentiated groups (p<0.05). No significant differences of TSP-1 positive expression were detected with clinical stage. TSP-1 positive expression was significantly lower in patients with cervical lymph node metastasis or relapse at 5 years (p<0.05). After 5 years, patients with positive TSP-1 expression had significantly higher tumor-free survival than patients with negative TSP-1. Positive Id-1 expression is associated with high malignancy/poor prognosis; positive TSP-1 expression is associated with low malignancy/good prognosis. Protein expression status may help assess tumor malignancy and patient prognosis.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
D
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
1399-0020
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2009 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
39
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
29-35
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| pubmed:meshHeading |
pubmed-meshheading:19906510-Adult,
pubmed-meshheading:19906510-Aged,
pubmed-meshheading:19906510-Carcinoma,
pubmed-meshheading:19906510-Carcinoma, Mucoepidermoid,
pubmed-meshheading:19906510-Cell Differentiation,
pubmed-meshheading:19906510-Coloring Agents,
pubmed-meshheading:19906510-Disease-Free Survival,
pubmed-meshheading:19906510-Female,
pubmed-meshheading:19906510-Follow-Up Studies,
pubmed-meshheading:19906510-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:19906510-Humans,
pubmed-meshheading:19906510-Immunohistochemistry,
pubmed-meshheading:19906510-Inhibitor of Differentiation Protein 1,
pubmed-meshheading:19906510-Lymphatic Metastasis,
pubmed-meshheading:19906510-Male,
pubmed-meshheading:19906510-Middle Aged,
pubmed-meshheading:19906510-Neoplasm Recurrence, Local,
pubmed-meshheading:19906510-Neoplasm Staging,
pubmed-meshheading:19906510-Parotid Gland,
pubmed-meshheading:19906510-Prognosis,
pubmed-meshheading:19906510-Retrospective Studies,
pubmed-meshheading:19906510-Salivary Gland Neoplasms,
pubmed-meshheading:19906510-Submandibular Gland,
pubmed-meshheading:19906510-Survival Rate,
pubmed-meshheading:19906510-Thrombospondin 1,
pubmed-meshheading:19906510-Tumor Markers, Biological
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| pubmed:year |
2010
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| pubmed:articleTitle |
The alteration of Id-1 and TSP-1 expression in mucoepidermoid carcinoma associated with its clinical features and prognosis.
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| pubmed:affiliation |
State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, PR China.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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