| pubmed-article:19905893 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19905893 | lifeskim:mentions | umls-concept:C0006826 | lld:lifeskim |
| pubmed-article:19905893 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:19905893 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:19905893 | lifeskim:mentions | umls-concept:C0076934 | lld:lifeskim |
| pubmed-article:19905893 | lifeskim:mentions | umls-concept:C0600401 | lld:lifeskim |
| pubmed-article:19905893 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:19905893 | pubmed:dateCreated | 2010-4-13 | lld:pubmed |
| pubmed-article:19905893 | pubmed:abstractText | Nonviral integrating vectors can be used for expression of therapeutic genes. piggyBac (PB), a transposon/transposase system, has been used to efficiently generate induced pluripotent stems cells from somatic cells, without genetic alteration. In this paper, we apply PB transposition to express a chimeric antigen receptor (CAR) in primary human T cells. We demonstrate that T cells electroporated to introduce the PB transposon and transposase stably express CD19-specific CAR and when cultured on CD19(+) artificial antigen-presenting cells, numerically expand in a CAR-dependent manner, display a phenotype associated with both memory and effector T cell populations, and exhibit CD19-dependent killing of tumor targets. Integration of the PB transposon expressing CAR was not associated with genotoxicity, based on chromosome analysis. PB transposition for generating human T cells with redirected specificity to a desired target such as CD19 is a new genetic approach with therapeutic implications. | lld:pubmed |
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| pubmed-article:19905893 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19905893 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19905893 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19905893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19905893 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19905893 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:19905893 | pubmed:issn | 1557-7422 | lld:pubmed |
| pubmed-article:19905893 | pubmed:author | pubmed-author:ShpallElizabe... | lld:pubmed |
| pubmed-article:19905893 | pubmed:author | pubmed-author:HulsHelenH | lld:pubmed |
| pubmed-article:19905893 | pubmed:author | pubmed-author:RaoPulivarthi... | lld:pubmed |
| pubmed-article:19905893 | pubmed:author | pubmed-author:ChamplinRicha... | lld:pubmed |
| pubmed-article:19905893 | pubmed:author | pubmed-author:GottschalkSte... | lld:pubmed |
| pubmed-article:19905893 | pubmed:author | pubmed-author:KaminskiJosep... | lld:pubmed |
| pubmed-article:19905893 | pubmed:author | pubmed-author:WilsonMatthew... | lld:pubmed |
| pubmed-article:19905893 | pubmed:author | pubmed-author:CooperLaurenc... | lld:pubmed |
| pubmed-article:19905893 | pubmed:author | pubmed-author:NakazawaYozoY | lld:pubmed |
| pubmed-article:19905893 | pubmed:author | pubmed-author:KebriaeiParto... | lld:pubmed |
| pubmed-article:19905893 | pubmed:author | pubmed-author:SinghHarjeetH | lld:pubmed |
| pubmed-article:19905893 | pubmed:author | pubmed-author:LeeDean ADA | lld:pubmed |
| pubmed-article:19905893 | pubmed:author | pubmed-author:OlivaresSimon... | lld:pubmed |
| pubmed-article:19905893 | pubmed:author | pubmed-author:MiTiejuanT | lld:pubmed |
| pubmed-article:19905893 | pubmed:author | pubmed-author:MaitiSourindr... | lld:pubmed |
| pubmed-article:19905893 | pubmed:author | pubmed-author:DawsonMargare... | lld:pubmed |
| pubmed-article:19905893 | pubmed:author | pubmed-author:ManuriPallavi... | lld:pubmed |
| pubmed-article:19905893 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19905893 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:19905893 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19905893 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19905893 | pubmed:pagination | 427-37 | lld:pubmed |
| pubmed-article:19905893 | pubmed:dateRevised | 2011-7-27 | lld:pubmed |
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| pubmed-article:19905893 | pubmed:meshHeading | pubmed-meshheading:19905893... | lld:pubmed |
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| pubmed-article:19905893 | pubmed:meshHeading | pubmed-meshheading:19905893... | lld:pubmed |
