Linked Life Data

19905158

Source:http://linkedlifedata.com/resource/pubmed/id/19905158

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3 Pt 1
pubmed:dateCreated
2009-11-12
pubmed:abstractText
In multicellular organisms, epithelial cells form layers separating compartments responsible for different physiological functions. At the early stage of epithelial layer formation, each cell of an aggregate defines an inner and an outer side by breaking the symmetry of its initial state, in a process known as epithelial polarization. By integrating recent biochemical and biophysical data with stochastic simulations of the relevant reaction-diffusion system, we provide evidence that epithelial cell polarization is a chemical phase-separation process induced by a local bistability in the signaling network at the level of the cell membrane. The early symmetry breaking event triggering phase separation is induced by adhesion-dependent mechanical forces localized in the point of convergence of cell surfaces when a threshold number of confluent cells is reached. The generality of the emerging phase-separation scenario is likely common to many processes of cell polarity formation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1550-2376
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
80
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
031919
pubmed:dateRevised
2010-3-2
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Symmetry breaking mechanism for epithelial cell polarization.
pubmed:affiliation
Department of Oncological Sciences and Division of Vascular Biology, Institute for Cancer Research and Treatment, School of Medicine, University of Torino, 10060 Candiolo, Torino, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't