Source:http://linkedlifedata.com/resource/pubmed/id/19904755
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
2010-4-19
|
| pubmed:abstractText |
We investigated whether there was an association between GBV-C viremia and the development of non-Hodgkin lymphoma (NHL) in 553 NHL cases and 438 controls from British Columbia, Canada. Cases were aged 20-79, diagnosed between March 2000 and February 2004, and resident in Greater Vancouver or Victoria. Cases and controls were tested for GBV-C RNA by RT-PCR and positive samples were genotyped. Overall, GBV-C RNA was detected in 4.5% of NHL cases vs. 1.8% of controls [adjusted odds ratio (OR) = 2.72, 95% confidence interval (CI) = 1.22-6.69]. The association between GBV-C RNA detection and NHL remained even after individuals with a history of prior transfusion, injection drug use and hepatitis C virus sero-positivity were excluded. GBV-C viremia showed the strongest association with diffuse large B cell lymphoma (adjusted OR = 5.18, 95% CI = 2.06-13.71). Genotyping was performed on 29/33 GBV-C RNA positive individuals; genotypes 2a (n = 22); 2b (n = 5) and 3 (n = 2) were identified, consistent with the distribution of genotypes found in North America. This is the largest case-control study to date associating GBV-C viremia and NHL risk. As GBV-C is known to be transmitted through blood products this may have important implications for blood safety.
|
| pubmed:grant | |
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
1097-0215
|
| pubmed:author |
pubmed-author:BraybrookHeatherH,
pubmed-author:Brooks-WilsonAngela RAR,
pubmed-author:ChowRonR,
pubmed-author:ConnorsJoseph MJM,
pubmed-author:CookDarrelD,
pubmed-author:GallagherRichard PRP,
pubmed-author:GascoyneRandy DRD,
pubmed-author:KrajdenMelM,
pubmed-author:LaiAgnes SAS,
pubmed-author:MakAnnieA,
pubmed-author:PetricMartinM,
pubmed-author:SpinelliJohn JJJ,
pubmed-author:TellierRaymondR,
pubmed-author:YuAmandaA
|
| pubmed:issnType |
Electronic
|
| pubmed:day |
15
|
| pubmed:volume |
126
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2885-92
|
| pubmed:dateRevised |
2011-6-10
|
| pubmed:meshHeading |
pubmed-meshheading:19904755-Adult,
pubmed-meshheading:19904755-Aged,
pubmed-meshheading:19904755-Case-Control Studies,
pubmed-meshheading:19904755-Female,
pubmed-meshheading:19904755-Flaviviridae Infections,
pubmed-meshheading:19904755-GB virus C,
pubmed-meshheading:19904755-Hepatitis, Viral, Human,
pubmed-meshheading:19904755-Humans,
pubmed-meshheading:19904755-Lymphoma, Non-Hodgkin,
pubmed-meshheading:19904755-Male,
pubmed-meshheading:19904755-Middle Aged,
pubmed-meshheading:19904755-Pregnancy,
pubmed-meshheading:19904755-Prevalence,
pubmed-meshheading:19904755-Prognosis,
pubmed-meshheading:19904755-RNA, Messenger,
pubmed-meshheading:19904755-RNA, Viral,
pubmed-meshheading:19904755-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19904755-Risk Factors,
pubmed-meshheading:19904755-Young Adult
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
GBV-C/hepatitis G virus infection and non-Hodgkin lymphoma: a case control study.
|
| pubmed:affiliation |
British Columbia Centre for Disease Control, Vancouver, BC, Canada. mel.krajden@bccdc.ca
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|