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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2009-11-11
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pubmed:abstractText |
Mesenchymal stromal cells (MSC) have been thought to be attractive candidates for the treatment of Duchenne muscular dystrophy (DMD), but the rate of MSC myogenesis is very low. Thus MSC treatment for DMD is restricted. Myostatin (Mstn), a negative regulator of myogenesis, is known to be responsible for limiting skeletal muscle regeneration. We hypothesized that inhibition of Mstn by using anti-Mstn antibody (Ab) would ameliorate the myogenic differentiation of MSC in vitro and in vivo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1477-2566
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
849-63
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pubmed:meshHeading |
pubmed-meshheading:19903098-Animals,
pubmed-meshheading:19903098-Antibodies, Blocking,
pubmed-meshheading:19903098-Antigens, Differentiation,
pubmed-meshheading:19903098-Azacitidine,
pubmed-meshheading:19903098-Bone Marrow,
pubmed-meshheading:19903098-Cell Differentiation,
pubmed-meshheading:19903098-Cells, Cultured,
pubmed-meshheading:19903098-Male,
pubmed-meshheading:19903098-Mesenchymal Stem Cell Transplantation,
pubmed-meshheading:19903098-Mesenchymal Stem Cells,
pubmed-meshheading:19903098-Motor Activity,
pubmed-meshheading:19903098-Muscle Development,
pubmed-meshheading:19903098-Muscular Dystrophy, Duchenne,
pubmed-meshheading:19903098-Myostatin,
pubmed-meshheading:19903098-Rats,
pubmed-meshheading:19903098-Rats, Sprague-Dawley,
pubmed-meshheading:19903098-Stromal Cells
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pubmed:year |
2009
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pubmed:articleTitle |
Inhibition of myostatin promotes myogenic differentiation of rat bone marrow-derived mesenchymal stromal cells.
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pubmed:affiliation |
Neurology Department, The First Affiliated Hospital, Sun Yat-Sen University, Guang Zhou, PR China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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