Linked Life Data

19902058

Source:http://linkedlifedata.com/resource/pubmed/id/19902058

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2009-11-10
pubmed:abstractText
Latent inhibition of active avoidance reaction was acquired by mature Wistar rats. It manifested in marked delay of habit acquisition after preexposure to the conditional stimulus in the first experimental session. Single dose of NMDA-receptor antagonist memantine (10 and 14 mg/kg) was applied 60 min before training in the second session. Failure of latent inhibition formation was registered after administration of the higher memantine dose; it manifested in accelerated attaining of the criterion (7 successive conditioned avoidance reactions) compared to training results after administration of the lower dose or physiological saline. The effects of memantine on attention were found to depend on the presence of pathology. It was hypothesized that the preparation can produce a positive effect on memory in Alzheimer-type dementia due to primary recovery of the inhibitory aspect of attention.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1573-8221
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
147
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
691-4
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Effects of memantine on latent inhibition of active avoidance in wistar rats.
pubmed:affiliation
Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. loskutova@physiol.ru
pubmed:publicationType
Journal Article