Source:http://linkedlifedata.com/resource/pubmed/id/19899843
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2009-11-10
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| pubmed:abstractText |
The authors tested a model for the intergenerational transmission of depression integrating specific genetic (5-HTTLPR), cognitive (inferential style), and environmental (mother depressive symptoms and expressed-emotion criticism [EE-Crit]) risk factors. Supporting the hypothesis that maternal depression is associated with elevated levels of stress in children's lives, mothers with a history of major depressive disorder (MDD) exhibited higher depressive symptoms across a 6-month multiwave follow-up than mothers with no depression history. In addition, partially supporting our hypothesis, levels of maternal criticism during the follow-up were significantly related to mothers' current depressive symptoms but not to history of MDD. Finally, the authors found support for an integrated Gene x Cognition x Environment model of risk. Specifically, among children with negative inferential styles regarding their self-characteristics, there was a clear dose response of 5-HTTLPR genotype moderating the relation between maternal criticism and children's depressive symptoms, with the highest depressive symptoms during the follow-up observed among children carrying 2 copies of the 5-HTTLPR lower expressing alleles (short [S] or long [LG]) who also exhibited negative inferential styles for self-characteristics and who experienced high levels of EE-Crit. In contrast, children with positive inferential styles exhibited low depressive symptoms regardless of 5-HTTLPR genotype or level of maternal criticism.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
1939-1846
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| pubmed:author | |
| pubmed:copyrightInfo |
PsycINFO Database Record 2009 APA, all rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
118
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
734-45
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| pubmed:dateRevised |
2011-8-1
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| pubmed:meshHeading |
pubmed-meshheading:19899843-Adult,
pubmed-meshheading:19899843-Alleles,
pubmed-meshheading:19899843-Child,
pubmed-meshheading:19899843-Child of Impaired Parents,
pubmed-meshheading:19899843-Depressive Disorder, Major,
pubmed-meshheading:19899843-Expressed Emotion,
pubmed-meshheading:19899843-Female,
pubmed-meshheading:19899843-Genetic Predisposition to Disease,
pubmed-meshheading:19899843-Genotype,
pubmed-meshheading:19899843-Humans,
pubmed-meshheading:19899843-Male,
pubmed-meshheading:19899843-Middle Aged,
pubmed-meshheading:19899843-Models, Psychological,
pubmed-meshheading:19899843-Mother-Child Relations,
pubmed-meshheading:19899843-Parenting,
pubmed-meshheading:19899843-Phenotype,
pubmed-meshheading:19899843-Risk Factors,
pubmed-meshheading:19899843-Self Concept,
pubmed-meshheading:19899843-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:19899843-Social Environment
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| pubmed:year |
2009
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| pubmed:articleTitle |
Children's inferential styles, 5-HTTLPR genotype, and maternal expressed emotion-criticism: An integrated model for the intergenerational transmission of depression.
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| pubmed:affiliation |
Department of Psychology, Binghamton University, New York 13902-6000, USA. bgibb@binghamton.edu
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| pubmed:publicationType |
Journal Article
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