Source:http://linkedlifedata.com/resource/pubmed/id/19898904
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2010-1-12
|
| pubmed:abstractText |
A newly developed synthetic alpha v beta 3 integrin targeted optical probe (ITOP) has been demonstrated to target cancer cells, in vivo. Compared to the commercially available cyclic peptide c[RGDfv], this optical probe has at least 20 times better binding affinity for the alpha v beta 3 receptor. The present in vitro study was designed to investigate the possibility of detecting early atherosclerotic plaque by using this ITOP.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1860-2002
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
12
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2-8
|
| pubmed:meshHeading |
pubmed-meshheading:19898904-Animals,
pubmed-meshheading:19898904-Atherosclerosis,
pubmed-meshheading:19898904-Biological Markers,
pubmed-meshheading:19898904-Connective Tissue,
pubmed-meshheading:19898904-Diagnostic Imaging,
pubmed-meshheading:19898904-Early Diagnosis,
pubmed-meshheading:19898904-Integrin alphaVbeta3,
pubmed-meshheading:19898904-Microscopy, Fluorescence,
pubmed-meshheading:19898904-Molecular Probes,
pubmed-meshheading:19898904-Optical Phenomena,
pubmed-meshheading:19898904-Rabbits,
pubmed-meshheading:19898904-Staining and Labeling
|
| pubmed:articleTitle |
High-affinity alphavbeta3 integrin targeted optical probe as a new imaging biomarker for early atherosclerosis: initial studies in Watanabe rabbits.
|
| pubmed:affiliation |
Laboratory of Integrative Cardiovascular Imaging Science, National Institute of Diabetes Digestive and Kidney Diseases, Bethesda, MD 20892, USA. herouxj@nhlbi.nih.gov
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|