Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2009-11-25
pubmed:abstractText
Adverse early life events can induce long-lasting changes in physiology and behavior. We found that early-life stress (ELS) in mice caused enduring hypersecretion of corticosterone and alterations in passive stress coping and memory. This phenotype was accompanied by a persistent increase in arginine vasopressin (AVP) expression in neurons of the hypothalamic paraventricular nucleus and was reversed by an AVP receptor antagonist. Altered Avp expression was associated with sustained DNA hypomethylation of an important regulatory region that resisted age-related drifts in methylation and centered on those CpG residues that serve as DNA-binding sites for the methyl CpG-binding protein 2 (MeCP2). We found that neuronal activity controlled the ability of MeCP2 to regulate activity-dependent transcription of the Avp gene and induced epigenetic marking. Thus, ELS can dynamically control DNA methylation in postmitotic neurons to generate stable changes in Avp expression that trigger neuroendocrine and behavioral alterations that are frequent features in depression.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1546-1726
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1559-66
pubmed:dateRevised
2010-4-29
pubmed:meshHeading
pubmed-meshheading:19898468-Animals, pubmed-meshheading:19898468-Animals, Newborn, pubmed-meshheading:19898468-Arginine Vasopressin, pubmed-meshheading:19898468-Behavior, Animal, pubmed-meshheading:19898468-Corticosterone, pubmed-meshheading:19898468-DNA Methylation, pubmed-meshheading:19898468-Depression, pubmed-meshheading:19898468-Enhancer Elements, Genetic, pubmed-meshheading:19898468-Epigenesis, Genetic, pubmed-meshheading:19898468-Hypothalamo-Hypophyseal System, pubmed-meshheading:19898468-Methyl-CpG-Binding Protein 2, pubmed-meshheading:19898468-Mice, pubmed-meshheading:19898468-Neurons, pubmed-meshheading:19898468-Paraventricular Hypothalamic Nucleus, pubmed-meshheading:19898468-Phenotype, pubmed-meshheading:19898468-Phosphorylation, pubmed-meshheading:19898468-Stress, Physiological, pubmed-meshheading:19898468-Transcription, Genetic
pubmed:year
2009
pubmed:articleTitle
Dynamic DNA methylation programs persistent adverse effects of early-life stress.
pubmed:affiliation
Max Planck Institute of Psychiatry, Munich, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't