Linked Life Data

19897669

Source:http://linkedlifedata.com/resource/pubmed/id/19897669

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2010-1-1
pubmed:abstractText
Mitogen-activated protein kinase (MAPK) signaling networks regulate numerous eukaryotic biological processes. In Arabidopsis thaliana, signaling networks that contain MAPK kinases MKK4/5 and MAPKs MPK3/6 function in abiotic and biotic stress responses and regulate embryonic and stomatal development. However, how single MAPK modules direct specific output signals without cross-activating additional downstream processes is largely unknown. Studying relationships between MAPK components and downstream signaling outcomes is difficult because broad experimental manipulation of these networks is often lethal or associated with multiple phenotypes. Stomatal development in Arabidopsis follows a series of discrete, stereotyped divisions and cell state transitions. By expressing a panel of constitutively active MAPK kinase (MAPKK) variants in discrete stomatal lineage cell types, we identified a new inhibitory function of MKK4 and MKK5 in meristemoid self-renewal divisions. Furthermore, we established roles for MKK7 and MKK9 as both negative and (unexpectedly) positive regulators during the major stages of stomatal development. This has expanded the number of known MAPKKs that regulate stomatal development and allowed us to build plausible and testable subnetworks of signals. This in vivo cell type-specific assay can be adapted to study other protein families and thus may reveal insights into other complex signal transduction pathways in plants.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1532-298X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3506-17
pubmed:dateRevised
2010-11-2
pubmed:meshHeading
pubmed-meshheading:19897669-Arabidopsis, pubmed-meshheading:19897669-Arabidopsis Proteins, pubmed-meshheading:19897669-Biological Assay, pubmed-meshheading:19897669-Body Patterning, pubmed-meshheading:19897669-Cell Differentiation, pubmed-meshheading:19897669-Cell Division, pubmed-meshheading:19897669-Cell Lineage, pubmed-meshheading:19897669-Cell Proliferation, pubmed-meshheading:19897669-Gene Expression Regulation, Enzymologic, pubmed-meshheading:19897669-Gene Expression Regulation, Plant, pubmed-meshheading:19897669-Growth Inhibitors, pubmed-meshheading:19897669-MAP Kinase Kinase 7, pubmed-meshheading:19897669-MAP Kinase Signaling System, pubmed-meshheading:19897669-Meristem, pubmed-meshheading:19897669-Mitogen-Activated Protein Kinase Kinases, pubmed-meshheading:19897669-Mitogen-Activated Protein Kinases, pubmed-meshheading:19897669-Plant Stomata
pubmed:year
2009
pubmed:articleTitle
Novel and expanded roles for MAPK signaling in Arabidopsis stomatal cell fate revealed by cell type-specific manipulations.
pubmed:affiliation
Department of Biology, Stanford University, Stanford, CA 94305, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.