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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
2009-11-17
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pubmed:abstractText |
Nitric oxide-releasing alpha-tocopherol mimetics with LDL-protective activity were designed to maintain the tocopherol substructure necessary for its biochemical recognition by alpha-tocopherol transfer protein. In order to study the molecular interactions to alpha-TTP, theoretical binding studies by means of docking techniques and experimental binding assays, using a fluorescent probe, were performed. Furoxanyl-tocopherol-hybrid analogs 7 and 9 have the best ability to bind to alpha-TTP suggesting that they could be incorporated to LDL in vivo to further release nitric oxide and prevent oxidative modifications.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1464-3391
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8143-8
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pubmed:meshHeading |
pubmed-meshheading:19897374-Amino Acid Substitution,
pubmed-meshheading:19897374-Antioxidants,
pubmed-meshheading:19897374-Cholesterol, LDL,
pubmed-meshheading:19897374-Humans,
pubmed-meshheading:19897374-Molecular Sequence Data,
pubmed-meshheading:19897374-Nitric Oxide,
pubmed-meshheading:19897374-Nitric Oxide Donors,
pubmed-meshheading:19897374-Protein Binding,
pubmed-meshheading:19897374-Protein Conformation,
pubmed-meshheading:19897374-Structure-Activity Relationship,
pubmed-meshheading:19897374-Tocopherols,
pubmed-meshheading:19897374-Vitamin E,
pubmed-meshheading:19897374-alpha-Tocopherol
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pubmed:year |
2009
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pubmed:articleTitle |
Interaction studies between human alpha-tocopherol transfer protein and nitric oxide donor tocopherol analogues with LDL-protective activity.
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pubmed:affiliation |
Departamento de Química Orgánica, Facultad de Química-Facultad de Ciencias, Universidad de la República, Iguá 4225, 11400 Montevideo, Uruguay. vlopez@fq.edu.uy
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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