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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-12-9
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pubmed:abstractText |
Newcastle disease virus (NDV) is an avian paramyxovirus that exists as hundreds of strains with widely different virulence properties. The NDV V protein exhibits interferon (IFN) antagonistic activity, which contributes to the virulence of the virus. The IFN-antagonistic activities of the V proteins from the avirulent strain La Sota and the moderately virulent strain Beaudette C (BC) were compared in an assay for the rescue of a recombinant NDV expressing the green fluorescent protein (NDV-GFP). Consistent with the virulence properties of the two viruses, the BC V protein exhibits a 4-fold greater ability to rescue replication of NDV-GFP than the La Sota V protein. Four amino acid differences in the C-terminal region of V, as well as the N-terminal region, contribute to the difference in IFN-antagonistic activity between the two V proteins.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19896994-10233962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19896994-10933690,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19896994-10989186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19896994-11119610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19896994-11352671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19896994-11533180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19896994-11831692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19896994-11886243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19896994-12202220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19896994-12482655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19896994-12502864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19896994-12817444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19896994-12885886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19896994-14643634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19896994-16257582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19896994-16840332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19896994-17626104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19896994-18234267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19896994-19168110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19896994-2705298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19896994-3275436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19896994-4361457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19896994-7646364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19896994-8277263,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19896994-948870
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1872-7492
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
147
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
153-7
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pubmed:dateRevised |
2011-7-19
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pubmed:meshHeading |
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pubmed:year |
2010
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pubmed:articleTitle |
The interferon antagonistic activities of the V proteins from two strains of Newcastle disease virus correlate with their known virulence properties.
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pubmed:affiliation |
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Extramural
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