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rdf:type |
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lifeskim:mentions |
umls-concept:C0002006,
umls-concept:C0016055,
umls-concept:C0033414,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0220781,
umls-concept:C0227651,
umls-concept:C0597298,
umls-concept:C1366765,
umls-concept:C1621574,
umls-concept:C1883254
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pubmed:issue |
1
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pubmed:dateCreated |
2010-1-22
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pubmed:abstractText |
Aldosterone plays an important role in fibrosis. Recent studies showed that Na(+)-H(+) exchanger isoform 1 (NHE1) is involved in mineralocorticoid-induced organ fibrosis. In this study, we examined the role of NHE1 in aldosterone-induced fibronectin accumulation in rat mesangial cells and the signaling pathway involved.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1421-9670
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2009 S. Karger AG, Basel.
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pubmed:issnType |
Electronic
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
75-82
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pubmed:meshHeading |
pubmed-meshheading:19893300-Aldosterone,
pubmed-meshheading:19893300-Animals,
pubmed-meshheading:19893300-Cells, Cultured,
pubmed-meshheading:19893300-Fibronectins,
pubmed-meshheading:19893300-Male,
pubmed-meshheading:19893300-Mesangial Cells,
pubmed-meshheading:19893300-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:19893300-Protein Isoforms,
pubmed-meshheading:19893300-Rats,
pubmed-meshheading:19893300-Rats, Sprague-Dawley,
pubmed-meshheading:19893300-Sodium-Hydrogen Antiporter
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pubmed:year |
2010
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pubmed:articleTitle |
Aldosterone promotes fibronectin synthesis in rat mesangial cells via ERK1/2-stimulated Na-H+ exchanger isoform 1.
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pubmed:affiliation |
Division of Nephrology, Huashan Hospital, Shanghai, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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