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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2009-11-6
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pubmed:abstractText |
Hypoglycemia is a common adverse effect of sulfonylurea oral hypoglycemic agents. Impaired metabolism of sulfonylureas due to gene polymorphisms in the metabolic enzyme CYP2C9 might lead to hypoglycemia. In the present study we explored the association of the CYP2C9 variant alleles CYP2C9*2 and CYP2C9*3 with the incidence of hypoglycemic events in diabetic patients receiving the sulfonylureas glimepiride and gliclazide.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1744-8042
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1781-7
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pubmed:meshHeading |
pubmed-meshheading:19891554-Adult,
pubmed-meshheading:19891554-Aged,
pubmed-meshheading:19891554-Alleles,
pubmed-meshheading:19891554-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:19891554-Case-Control Studies,
pubmed-meshheading:19891554-Diabetes Mellitus, Type 2,
pubmed-meshheading:19891554-Female,
pubmed-meshheading:19891554-Genotype,
pubmed-meshheading:19891554-Humans,
pubmed-meshheading:19891554-Hypoglycemia,
pubmed-meshheading:19891554-Hypoglycemic Agents,
pubmed-meshheading:19891554-Male,
pubmed-meshheading:19891554-Middle Aged,
pubmed-meshheading:19891554-Risk,
pubmed-meshheading:19891554-Sulfonylurea Compounds
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pubmed:year |
2009
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pubmed:articleTitle |
Presence of CYP2C9*3 allele increases risk for hypoglycemia in Type 2 diabetic patients treated with sulfonylureas.
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pubmed:affiliation |
Laboratory of Pharmacology, Medical School, Democritus University of Thrace, Dragana Campus, 68100 Alexandroupolis, Greece.
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pubmed:publicationType |
Journal Article
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